There are more than 300 chemical reactions in the body which rely on magnesium, including enzyme activation, energy production and bone mineralization.   During these reactions Magnesium acts as a molecular cofactor supporting the reaction (including those converting food into energy) so when our bodies fall into a deficient status those reactions are negatively affected.

How do people become Magnesium deficient?

Approximately 80 percent of people have low levels of magnesium, meaning the chances are that you too have some level of deficiency.  Be aware that only 1 percent of magnesium in your body is in your bloodstream so it may be missed in blood tests.

Hypo Magnesia or Magnesium deficiency refers to inadequate intake of dietary magnesium or impaired absorption of magnesium and may occur due to:  

  • Reduced availability in the food supply, although Magnesium exists in foods like legumes, nuts, whole grains and green leafy vegetables. Modern farming practices and intensive farming has caused depletion of soils which has reduced the percentage of magnesium present in food. [i]
  • Absorption issues in the small intestine caused by digestive issues: celiac disease, Crohn’s disease, Leaky Gut, regional enteritis like IBD, or due to artificial shortening of the intestine because of weight loss surgery. All are known to reduce magnesium absorption. Magnesium absorption is also reduced because of the normal decline in our systems due to aging.  
  • Chronic disease and medication use has increased exponentially and much chronic illness is associated with magnesium deficiency and lack of mineral absorption. Medications may also cause damage to the gut (like ulceration) which is responsible for absorbing magnesium from our food and beverages. Medications which deplete Magnesium include: acid blockers (Tagamet, Nexium +), antacids (Maalox, Milk of Magnesia, AlkaSeltzer+), antibiotics (Amoxicillin, Doxycycline +), antiviral agents (Rescriptor, Foscavir+), birth control pills, blood pressure drugs (Apresoline), diuretics, and corticosteroids (Dexamethosone, Prednisone+) and many more [viii]  
  • Low Stomach Acid/Hypochlorhydria – the body needs appropriate stomach acid in order to break down minerals.
  • Alcohol dependency or regular use. Alcoholics often experience magnesium deficiency as alcohol is an “anti-nutrient”, drinking alcohol speeds up the excretion of magnesium through the kidneys. It can also deplete calcium, zinc, iron, manganese, potassium and chromium.  Alcohol also depletes the minerals in your body because it causes dehydration, biome imbalance, compromises the immune system, changes sleep patterns and premature aging.  
  • Soda, drinking soft drinks depletes your body of calcium and magnesium.
  • Coffee/Tea – calcium/magnesium are lost in our urine with caffeinated drinks as well as reserves of potassium and sodium.
  • Stress is also known to deplete levels of Magnesium in the body.

Signs of Magnesium Deficiency

Magnesium Migrane

Initial signs of deficiency may include:

  • Leg Cramps [ii]
  • Fatigue
  • Insomnia – potentially leading to sleep disorder
  • Restless Leg Syndrome (RLS)
  • Muscle Pain / Fibromyalgia.  A study published in Magnesium Research examined the role of magnesium in the management of symptoms of Fibromyalgia, finding that increased magnesium levels reduced pain and tenderness and also improved blood markers for immune health [iii].
  • Anxiety (irritability and nervousness, even panic attacks). Symptoms get worse as status of deficiency increases.
  • High Blood Pressure (Hypertension), Irregular Heartbeat and Risk of Stroke. A study with 241,378 participants published in the American Journal of Clinical Nutrition discovered that a diet high in magnesium rich foods could reduce the risk of a stroke by as much as 8 percent, profound considering that hypertension causes approximately 50 percent of ischemic strokes in the world [iv].
  • Type II Diabetes.  
    • Although Magnesium deficiency is considered one of 4 main causes of Diabetes Mellitus, it is also a common symptom of deficiency.   A Swedish study reported that the addition of magnesium supplementation (100 milligrams/day) lowered the risk of diabetes by 15 percent! [v]
    • In another study U.K. researcher, uncovered that of 1,452 adults examined low, magnesium levels were 10 times more common in new diabetics and 8.6 times more common with known diabetics. [vi]
  • Migraines 
    • Magnesium deficiency has been linked to migraine headaches because of its role in balancing the body's neurotransmitters and role in blood flow.  According to the Linus Pauling Institute, magnesium supplementation at a dose of 730 milligrams per day can cause a 12 percent improvement in the normal dilation response of arteries. It also decreases arterial wall dysfunction, resulting in better blood circulation.  An increase in blood flow to the brain is known to reduce the incidence of Migraines.  Improved blood flow also allows more blood to reach the heart and muscles of upper and lower extremities, potentially leading to an improvement in overall exercise and physical stress tolerance.  
    • Studies have shown that preventive treatment with oral magnesium and acute headache treatment with intravenous magnesium may be effective, particularly in certain subsets of patients. Daily Magnesium supplementation reduced the frequency of migraine headaches by up to 42 percent. [vii]
  • Bone Density (Rickets, Osteopenia and Osteoporosis) A study in Biology Trace Element Research showed that supplementation with Magnesium slowed the development of osteoporosis “significantly” after 30 days. (*Vitamins D3 and K2 should be taken in addition for best effect)
  • Other symptoms of deficiency are: constipation, hyper excitability, muscular symptoms (cramps, tremors, fasciculations, spasms, tetany (types of contraction), weakness), fatigue, loss of appetite, apathy, confusion, irritability, poor memory, loss of focus and reduced ability to learn


Magnesium significantly reduces the absorption of oral bisphosphonates and tetracycline antibiotics and may reduce their activity



[i] .

UK Study Shows Decline in Mineral Content of Fruit and Vegetables.  Bergner P. The Healing Power of Minerals, Special Nutrients and Trace Elements; Prima Publishing.

[ii]   Can Fam Physician. 1996 Jul;42:1348-51.

Muscle cramps and magnesium deficiency: case reports. Bilbey DL1, Prabhakaran VM..

[iii]  Magnes Res. 1994 Dec;7(3-4):285-8.

Selenium and magnesium status in fibromyalgia. Eisinger J1, Plantamura A, Marie PA, Ayavou T.

[iv]  American Journal of Clinical Nutrition 2012 Feb;95(2):362-6. doi: 10.3945/ajcn.111.022376. Epub 2011 Dec 28.

Dietary magnesium intake and risk of stroke: a meta-analysis of prospective studies. Larsson SC1, Orsini N, Wolk A.

[v]  J Intern Med. 2007 Aug;262(2):208-14.

Magnesium intake and risk of type 2 diabetes: a meta-analysis.   Larsson SC1, Wolk A.

[vi]  Diabetes Res Clin Pract. 2010 Feb;87(2):261-6.  doi: 10.1016/j.diabres.2009.11.003. Epub 2009 Dec 8.

Hypomagnesaemia is associated with diabetes: Not pre-diabetes, obesity or the metabolic syndrome.

Simmons D1, Joshi S, Shaw J.


Expert Rev Neurother. 2009 Mar;9(3):369-79. doi: 10.1586/14737175.9.3.369.

Role of magnesium in the pathogenesis and treatment of migraine.   Sun-Edelstein C1, Mauskop A.

[viii]  From Drug Muggers: Which Medications Are Robbing Your Body of Essential Nutrients--and Natural Ways to Restore Them Suzy Cohen, R.Ph

Leave a comment

Please note: comments must be approved before they are published.